>99% Purity EU Warehouse

MOTS-c

Name: MOTS-c — Research Peptide UK
Brand: UK Peptides
Price: 130 EUR
Availability: InStock

Mitochondrial peptide activating the AMPK pathway — insulin sensitivity and metabolic research

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20 mg €130 40 mg €208 60 mg €312

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Temperature: -20°C (lyophilised) / 2–8°C (reconstituted)

Conditions: Protect from light and moisture

Shelf Life: 18 months (lyophilised)

Research Profile

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial genome — the first hormone discovered to be encoded by mitochondrial DNA. Identified by Lee et al. at the University of Southern California in 2015, MOTS-c activates the AMPK (AMP-activated protein kinase) pathway, a master regulator of cellular energy homeostasis. Research has documented improved insulin sensitivity, reduced adipogenesis, enhanced exercise capacity, and longevity-associated effects in animal models. It is considered a mitokine — a mitochondria-derived signalling molecule with systemic effects.

Reconstitution

Solvent: Bac Water (0.9% benzyl alcohol)

Volume: 1–2 mL

Concentration: 10 mg/mL at 1 mL

Key Research Findings

First hormone encoded by mitochondrial DNA (Lee et al., Cell Metabolism 2015)
Activates AMPK pathway — master regulator of energy homeostasis
Improved insulin sensitivity in diet-induced obesity mouse models
Reduced adipogenesis and increased fatty acid oxidation in vitro
Enhanced skeletal muscle glucose uptake independent of insulin
Circulating MOTS-c levels decline with age in humans and rodents

Lee C. et al., "The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance", Cell Metabolism, Vol. 21, pp. 443–454 (2015). Published research includes murine models of diet-induced obesity, skeletal muscle metabolism, and age-related insulin resistance.