Name: TB-500 — Research Peptide UK
Brand: UK Peptides
Price: 135 EUR
Availability: InStock

TB-500

Thymosin Beta-4 fragment — muscle recovery and tissue regeneration research

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10 mg €135 20 mg €216 30 mg €365

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Temperature: -20°C (lyophilised) / 2–8°C (reconstituted)

Conditions: Protect from light and moisture

Shelf Life: 24 months (lyophilised)

Research Profile

TB-500 is a synthetic analogue of the actin-sequestering domain of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid peptide found in virtually all nucleated cells. The active fragment (amino acids 17–23, sequence Ac-LKKTETQ) retains the core biological activity of full-length Tβ4 and is substantially more stable. Research focuses on its ability to upregulate actin polymerisation, promote cell migration, and stimulate angiogenesis — processes central to tissue repair. Published studies in cardiac, musculoskeletal, and ocular repair models document significant regenerative activity. TB-500 also exhibits anti-inflammatory properties relevant to chronic injury research.

Reconstitution

Solvent: Bac Water (0.9% benzyl alcohol)

Volume: 1–2 mL

Concentration: 10 mg/mL at 1 mL

Key Research Findings

Promotes cell migration and proliferation in wound healing models

Cardiac repair potential documented in murine myocardial infarction studies (Nature 2004)

Upregulates actin polymerisation for cytoskeletal reorganisation

Anti-inflammatory properties via down-regulation of NF-kB signalling

Skeletal muscle regeneration in satellite cell studies

Thymosin Beta-4 research has been ongoing since the 1960s (Goldstein et al.). The synthetic TB-500 fragment has been studied in preclinical models for cardiac repair (Bock-Marquette et al., Nature 2004), wound healing, and skeletal muscle regeneration. RegeneRx Biopharmaceuticals has advanced full-length Tβ4 into Phase II clinical trials.

Related Research Compounds